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Decode your DNA and Transform your health with Nutrigenomics.

Experience a truly individualised functional medicine approach with precision nutrition and supplement-dosing based on your unique genetic blueprint.
Targeted Genomic Testing Panels & Precision Nutrition | By renowned Functional Medicine Practitioner Jo Gamble | Virtual Consultation | Convenient at-home DNA testing

Life changing results from patients

Jo Gamble has a very deep understanding of the complex underlying nutritional imbalances that need to be addressed to combat serious illnesses in conjunction with medication prescribed by specialists. She has been a godsend to me with her gentle and caring manner and her expertise provides me with a second opinion that I trust and cherish.
Anonymous client of jo gamble.

Nutrigenomics could be right for you if you...

  • Have a chronic health condition and want to understand how your epigenetics could be influencing your health.
  • Suffer with symptoms of hormonal imbalance or need support through Peri-Menopause and Menopause.
  • Have a family history of chronic disease like dementia, cardiovascular disease or cancer and want to minimise your risk of disease.
  • Are concerned about toxin-related health conditions and want to learn about your body’s detoxification processes.
  • Have MCAS, Anxiety or a neurological condition and want targeted strategies to reduce your symptoms.
  • Want a truly targeted diet and lifestyle plan that’s built on your unique biology.
JO Gamble Advanced Functional Medicine Practitioner & expert in Nutrigenomics

“Nutrigenomics uses epigenetic modifications to bathe the individual genome in the optimal environment. This is personalised medicine from the root up.”

Jo Gamble, BA (HONS) DIP CNM AFMCP FELLOW ICT
IFM Certified Practitioner, Integrative Cancer Fellow, Head of Functional Testing

Empower yourself with life-long knowledge.

Gain vital insights into your genomics and transform your health choices now and in the future.

What is Nutrigenomics?

Your DNA holds the key to your health, revealing how your body processes everything from toxins to hormones. Tiny genetic variations, known as SNPs, influence everything from nutrient absorption to disease risk, shaping your biology in ways you might not even realize.

But your genes are not your destiny. Environmental factors—stress, sleep, nutrition, even toxins—can activate or suppress your genes, affecting your health. This means your well-being is not set in stone. By tapping into the science of Nutrigenomics, we decode your genetic makeup, giving you the precise tools to make high-impact diet and lifestyle choices tailored to your body’s needs.

And it's not just for adults—Nutrigenomics can help optimise the health of children as well. By understanding their unique genetic blueprint, we can proactively make adjustments to support their growth, development, and future wellbeing. This approach helps prevent illness before it even begins, setting them on the path to lifelong health.

Ready to unlock your genetic potential?

Nutrigenomics can...

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Uncover your biological strengths and reduce unnecessary protocols and interventions.
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Uncover your biological weaknesses to identify pathways in need of targeted evidence-based intervention and support.
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Identify invisible sensitivities to foods or environmental pollutants that may be impacting your health.
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Help you understand why you may or may not be responding well to a particular protocol.
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Help you or your child reduce your risk of developing certain health conditions and disease.
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Support an existing health plan by enabling precision supplement dosing.

We partner with Lifecode Gx®, experts in Nutrigenomics genotype analysis to offer nine advanced genetic testing panels. Get a detailed, personalised look at how your genes interact with your diet and environment, all from a simple cheek swab. It's more than just a test—it's a roadmap to better health.

Access detailed analysis of how genetic variations influence your health, providing precise insights into how your body processes vitamins, minerals, and other nutrients that impact nutrient status, detoxification, cardiovascular health and sleep.

Is it for me?

The Nutrient Core Report provides essential insights into a wide range of health conditions, especially when used alongside other panels. Your practitioner will design a tailored testing plan, but it can be particularly valuable for:
  • Vitamin and Mineral Deficiencies: Identifies risk factors for deficiencies helping prevent imbalances.
  • Metabolic Disorders: Offers insights into genetic factors that could increase your risk for metabolic and oxidative stress-related illness.
  • Digestive Issues: Highlights genetic predispositions for food intolerances and gut microbiome diversity.
  • Blood Pressure and Cardiovascular Risk: Assesses your genetic risk for salt-sensitive hypertension.
  • Chronic Inflammation: Identifies genetic markers that may predispose you to systemic inflammation.
It can be beneficial in combination with other panels for the following conditions:
  • Childhood Immune Support & Pre & Post Vaccine Insights: When combined with Methylation & Detoxification Panels.

Key Areas Analysed

  • Nutrient Metabolism: Identifies genetic variations related to how your body processes and utilises nutrients like vitamins, minerals, and antioxidants.
  • Dietary Recommendations: Offers personalised dietary advice based on your genetic profile to optimise nutrient intake.
  • Nutrient Interactions: Examines how your genes interact with certain nutrients, drugs, and other dietary components, helping optimise nutrient bioavailability and effectiveness.
  • Disease Risk Assessment: Provides insights into your genetic predisposition to conditions like vitamin deficiencies, metabolic disorders, and oxidative stress-related diseases..

Genes Tested

The Panel analyses the following SNPs which can shape your biological processes, influencing:
  • HLA-DQA1, HLA-DQB1 – Gluten sensitivity (Or Coeliac disease)
  • LCT – Lactose tolerance/intolerance
  • CYP1A2 – Caffeine metabolism and sensitivity
  • ADORA2A – Caffeine sensitivity
  • FUT2 – Microbiome diversity and gut health
  • BCO1 – Vitamin A metabolism
  • MTHFR – Folate metabolism and methylation
  • TCN2 – Vitamin B12 transport
  • SLC23A1 – Vitamin C absorption
  • COL1A1 – Vitamin D receptor
  • GC – Vitamin D binding protein
  • VDR – Vitamin D sensitivity
  • VKORC1 – Vitamin K metabolism
  • ACE, AGT – Blood pressure regulation and salt sensitivity
  • GSTM1 – Detoxification ability (Glutathione production)
  • TNF, IFNG – Inflammation and immune response
  • CLOCK, PER1 – Circadian rhythm and sleep patterns
By understanding these genetic factors, the Nutrient Core Report allows you to make informed decisions about your health, offering a tailored approach to diet, supplementation, and lifestyle. This personalised blueprint helps optimise your nutrition and wellbeing while addressing any potential health risks, guiding you toward better overall health.

Gain personalised insights into your genetic metabolic profile, helping you optimise metabolism, improve nutrient utilisation, and enhance overall health and well-being. The Metabolic Panel provides a detailed look at how your genes influence energy production, nutrient metabolism, weight management, detoxification, and hormone regulation.

Is it for me?

The Metabolic Panel provides vital insights into a wide range of health conditions, particularly when combined with other reports. It can be especially useful for:
  • Weight Management: Identifies genetic factors that influence your body’s ability to manage weight, regulate appetite, and store fat, helping you optimise your approach to weight loss or maintenance.
  • Metabolic Disorders: Offers valuable insights into your genetic risk for metabolic diseases like obesity, diabetes, and metabolic syndrome.
  • Blood Sugar Imbalances: Assesses genetic markers associated with insulin sensitivity, glucose metabolism, and the risk of insulin resistance or Type 2 diabetes.
  • Cardiovascular Risk: Provides a deeper understanding of your genetic predispositions for lipid imbalances, cholesterol metabolism, and overall heart health.
  • Detoxification and Environmental Sensitivity: Assesses your body's genetic capacity to detoxify harmful substances, including pollutants, drugs, and metabolic waste, supporting tailored detoxification strategies.
  • Inflammation and Chronic Disease: Identifies genetic markers that influence inflammatory responses, helping you manage oxidative stress and reduce the risk of inflammation-related conditions.
It can be beneficial in combination with other panels for the following conditions:
  • Peri-Menopause Support: When combined with a Hormone Panel.

Key Areas Analysed

  • Nutrient Metabolism: Assesses genetic variations in enzymes and pathways responsible for the digestion, absorption, transport, and storage of nutrients like carbohydrates, fats, proteins, vitamins, and minerals.
  • Energy Metabolism: Evaluates genetic factors affecting metabolic rate, energy expenditure, thermogenesis, and adipose tissue regulation. Includes genes involved in mitochondrial function, glucose metabolism, and hormonal regulation of metabolism.
  • Weight Regulation: Provides insights into how your genes influence energy balance, appetite regulation, fat storage, and your response to dietary interventions and exercise.
  • Insulin Sensitivity and Blood Sugar Regulation: Analyses genetic variations associated with insulin sensitivity, glucose metabolism, and blood sugar control. This includes genes related to insulin signalling, glucose uptake, and insulin resistance.
  • Lipid Metabolism and Cardiovascular Health: Evaluates genetic factors related to cholesterol metabolism, lipoprotein transport, lipid levels, and cardiovascular disease risk.
  • Detoxification Pathways: Assesses genetic variations in enzymes and pathways involved in the detoxification and elimination of toxins, metabolic by-products, and pollutants.
  • Inflammatory Response: Provides insights into how genetic variations impact inflammatory pathways, immune function, and oxidative stress, which can influence metabolic health and the risk of inflammatory conditions.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Appetite Regulation
    BDNF, FAAH, FTO, LEPR, MC4R, NPY, POMC – Genes involved in hunger, satiety, and appetite regulation, affecting your response to food intake and fat storage.
  • Nutrient Sensing
    ADIPOQ, FOXO3, HIF1A, IRS1, PARP1, PGC1A, PPARA, PPARG, SIRT1, VEGFA – Genes related to nutrient sensing and metabolic regulation, influencing how your body responds to different nutrients.
  • Sugar Metabolism
    AMPD1, GCK, GLUT2, IRS1, PPARG, TCF7L2 – Genetic variations affecting glucose metabolism, insulin sensitivity, and blood sugar regulation.
  • Fat Metabolism
    ADRB3, CD36, CPT1A, FABP2, LPL, PLIN1, PPARA, SREBF1 – Genes involved in fat storage, energy expenditure, and lipid metabolism.
  • Cholesterol and Bile
    CYP7A1, HMGCR, LDLR, SREBF1 – Genetic factors influencing cholesterol synthesis, transport, and clearance.
  • Mitochondria and Inflammation
    CAT, CRP, FOXO3, GPX1, IFNG, IL6, NRF2, SIRT3, SOD2, TNF, UCP1/2/3 – Genes that influence mitochondrial function, oxidative stress, inflammation, and the body’s ability to combat metabolic diseases.
By understanding these genetic factors, the Metabolic Panel empowers you to make informed health choices that can optimise metabolism, manage weight, support cardiovascular health, and reduce the risk of metabolic disorders

Gain personalised insights into your genetic detoxification profile, offering valuable information to support detoxification pathways, optimise health outcomes, and reduce the risk of toxin-related health conditions. The Detoxification Panel provides a detailed analysis of how your genes influence the body’s ability to eliminate toxic substances and optimize detoxification processes.

Is it for me?

The Detoxification Panel provides vital insights into a wide range of health conditions, particularly when combined with other reports. It can be especially useful for:
  • Headaches: Identifies genetic factors that may impair your body’s ability to clear toxins, which can lead to frequent or chronic headaches.
  • Fatigue: Helps pinpoint detoxification inefficiencies that contribute to fatigue and low energy levels.
  • Allergies: Offers insights into genetic susceptibilities to allergies, particularly those related to environmental toxins and pollutants.
  • Skin Disorders: Assesses your detoxification capacity, which can influence the development of skin issues like acne, eczema, or rashes due to toxin build-up.
  • Weight Gain: Identifies detoxification imbalances that could contribute to difficulty losing weight or unexplained weight gain.
    Bloating and Digestive Issues: Highlights genetic predispositions to digestive issues caused by the body’s inability to properly detoxify.
  • Acid Reflux and Heartburn: Offers insights into how poor detoxification may contribute to digestive discomfort and acid reflux.
  • Chronic Infections: Assesses your detoxification capacity and immune function, helping explain chronic infections or slow recovery from illness.
  • Fertility and Low Libido: Identifies detoxification-related genetic factors that could affect hormone regulation, leading to fertility issues or low libido.
  • Cognitive Decline: Helps determine how inefficient detoxification could contribute to brain fog, poor concentration, and other cognitive issues.
  • Low Stress Tolerance: Identifies genetic factors related to detoxification that may contribute to poor stress management and emotional resilience.
It can be beneficial in combination with other panels for the following conditions:
  • Childhood Immune Support & Pre & Post Vaccine Insights: When combined with Methylation & Nutrient Core Panels.

Key Areas Analysed

  • Detoxification Pathways:Identifies genetic variations in key enzymes and pathways involved in Phase I (activation) and Phase II (conjugation) detoxification processes.
  • Metabolic Capacity: Assesses your genetic metabolic capacity for detoxification, highlighting any genetic variations that may influence the efficiency of detoxification and your susceptibility to environmental toxins and drug metabolism.
  • Toxin Sensitivity: Evaluates genetic predispositions to toxin sensitivity, including detoxification enzyme activity, toxin clearance rates, and oxidative stress response pathways.
  • Nutrient Support:Provides tailored recommendations for nutritional support to optimise detoxification pathways, enhance toxin clearance, and support liver function and antioxidant defences.
  • Disease Risk Assessment: Assesses your genetic susceptibility to conditions linked to toxin exposure, oxidative stress, and impaired detoxification, including cancer, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome.
  • Environmental Sensitivity:Provides insights into how your genetic makeup interacts with environmental factors, lifestyle choices, and dietary habits to impact detoxification capacity and overall health outcomes.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • CYP450 Enzymes
    CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 – Genes involved in the metabolism of toxins, medications, and environmental pollutants through Phase I detoxification pathways.
  • Alcohol Metabolism
    ADH1B, ADH1C, ALDH2 – Genetic variations that affect alcohol metabolism and alcohol sensitivity.
  • Pesticide Sensitivity
    PON1 – Variations influencing the body’s ability to metabolise and eliminate pesticides.
  • Reactive Oxygen Species (ROS) Response
    SOD2, GPX1, NQO1 – Genes that help neutralise ROS, which are generated during the detoxification process in Phase I.
  • Glucuronidation
    UGT1A1, UGT1A6 – Involved in Phase II detoxification, which helps in the conjugation and excretion of toxins.
  • Methylation
    COMT, TPMT – Genetic variations that influence the body’s methylation process, important for detoxifying environmental toxins and maintaining immune function.
  • Sulphonation
    SULT1A1, SULT1E1, SULT2A1 – These genes are involved in the sulphonation process, another key Phase II pathway for detoxification.
  • Acetylation
    NAT1, NAT2 – Genes that affect the body’s ability to metabolise and eliminate certain drugs, toxins, and pollutants.
  • Glutathione Production
    GSTM1, GSTP1, GSTT1 – These genes are responsible for glutathione production, a key antioxidant involved in detoxification and the neutralisation of harmful substances.
  • Antiporter Function
    ABCB1 – A gene that affects the transport of medicines and other substances into and out of cells, influencing detoxification capacity.
By understanding these genetic factors, the Detoxification Panel empowers you to make informed decisions about your health. This personalised blueprint helps optimise detoxification pathways, reduce toxin exposure, and guide lifestyle and dietary choices to support your body's natural detox processes.

Gain personalised insights into your genetic methylation profile, offering valuable information to support optimal methylation function, reduce disease risk, and improve overall health and well-being. The Methylation Panel looks at how methylation affects critical processes in your body, influencing gene expression, cellular function, and various physiological processes that keep you healthy.

Is it for me?

The Methylation Panel provides vital insights into a wide range of health conditions, particularly when combined with other reports. It can be especially useful for:
  • Neurological & Neurodevelopmental Disorders: Methylation plays a role in the synthesis and metabolism of neurotransmitters like serotonin and dopamine, which are crucial for mood regulation and brain function. Disruptions can contribute to mood disorders, cognitive decline, and symptoms related to ADHD & Autism.
  • Cardiovascular Health: Proper methylation helps regulate homocysteine levels, which, when elevated, can damage blood vessels and lead to heart disease. Identifying methylation issues can help reduce your cardiovascular risk.
  • Cancer Risk: Methylation influences how genes are expressed, including those that regulate cell growth. Poor methylation can lead to uncontrolled cell division and the development of cancer.
  • Metabolic Disorders: Methylation supports numerous metabolic functions in the body. Imbalances can contribute to obesity, insulin resistance, and metabolic syndrome.
  • Aging and Cellular Repair: As we age, our methylation patterns change, which can slow down cellular repair and regeneration. Methylation issues can contribute to premature aging and reduced detoxification capacity.
  • Pregnancy & Fetal Development: Methylation is crucial during pregnancy for proper fetal development, particularly in cell differentiation and organ formation. Issues with methylation during pregnancy can affect the health and development of the fetus.
  • Mental Health and Mood: Poor methylation can affect brain chemistry, leading to conditions like depression, anxiety, and other psychiatric disorders.
It can be beneficial in combination with other panels for the following conditions:
  • Childhood Immune Support & Pre & Post Vaccine Insights: When combined with Nutrient Core & Detoxification Panels.

Key Areas Analysed

  • DNA Methylation Patterns: DNA methylation is a key process where methyl groups are added to DNA, influencing whether certain genes are active or inactive. This can affect everything from how cells grow to how they repair themselves.
  • Epigenetic Regulation: Methylation plays a role in epigenetics, which controls how your genes are expressed without changing the underlying DNA. For example, proper methylation can affect cell growth and tissue development, while poor methylation may increase the risk of certain health conditions.
  • Methylation Pathways: Methylation relies on several metabolic pathways in the body that provide the necessary nutrients (such as folate and vitamin B12) to keep the process running smoothly. Disruptions in these pathways can affect everything from energy production to detoxification.
  • Homocysteine Metabolism: Homocysteine is an amino acid that, when elevated, can damage blood vessels and increase the risk of cardiovascular diseases. Proper methylation helps convert homocysteine into other substances, reducing this risk.
  • Nutrient Requirements: Your body needs certain nutrients to support methylation. Depending on your genetic profile, you might require more of specific vitamins (e.g., folate, vitamin B12) to keep your methylation pathways functioning properly.
  • Disease Risk Assessment: Poor methylation can contribute to a range of health conditions, such as cardiovascular disease, cancer, and mental health issues. This panel helps identify your genetic risk factors for these diseases by looking at your methylation pathways.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Folate Cycle
    DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1, TYMS – These genes are involved in the body’s ability to use folate (a key B-vitamin) to support methylation.
  • Methionine Cycle
    AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT, TCN2 – These genes are part of a cycle that helps produce methionine, which is needed for proper methylation.
  • Neurotransmitter Cycle
    COMT, MAOA, MAOB, MTHFR, PNMT, QDPR, VDR – These genes influence the production and regulation of neurotransmitters like dopamine and serotonin, which affect mood, cognition, and behaviour.
  • Transsulfuration Cycle
    CBS, CTH, GSS, MUT, SUOX – These genes regulate sulphur-containing compounds that help detoxify the body and protect against oxidative stress
By understanding these genetic factors, the Methylation Panel empowers you to make informed decisions about your health. This personalised blueprint helps optimise methylation pathways, reduce disease risk, and guide lifestyle and dietary choices for better overall health and well-being.

Gain personalised insights into your genetic hormone profile, offering valuable information to support hormone balance, optimise reproductive health, manage hormone-related conditions, and improve overall well-being. The Hormones Panel focuses on steroid hormones and their regulation, offering a comprehensive view of how genetic factors influence hormone metabolism and imbalance.

Is it for me?

The Hormones Panel offers personalised insights into hormone balance for both men and women. It is particularly useful for addressing a wide range of hormone-related conditions, including:
  • Cortisol Imbalances (Cushing’s Syndrome & Addison’s Disease)
    Helps pinpoint genetic variations affecting cortisol metabolism, contributing to symptoms like weight gain, fatigue, and blood pressure fluctuations.
  • Bone Density Issues & Osteoporosis
    Identifies genetic factors that influence oestrogen, helping assess the risk of bone density loss linked to hormonal imbalances.
  • Low Libido, Fatigue & Muscle Loss
    Reveals genetic predispositions to low testosterone and cortisol imbalances which can contribute to sexual dysfunction and fatigue
  • Acne & Skin Issues
    Identifies hormonal imbalances, particularly excess androgens, that can contribute to excessive oil production or breakouts.
  • Baldness or Excessive Hair Growth
    Helps identify genetic variations linked to deficiencies or excesses of sex hormones that can contribute to male-pattern baldness or unwanted facial and body hair growth in women.
  • Fertility Issues, Endometriosis & Fibroids
    Pinpoints genetic variations that impact hormone regulation, helping manage fertility issues and conditions like, endometriosis, and fibroids.
  • Irregular Periods, Menstrual Dysfunction & PCOS
    Identifies hormonal imbalances that contribute to menstrual irregularities and conditions like PCOS and oestrogen dominance.
  • Mood Swings, Anxiety & PMS
    Reveals how variations in cortisol, oestrogen, and progesterone contribute to mood swings, anxiety, and PMS symptoms.
It can be beneficial in combination with other panels for the following conditions:
  • Mast Cell Activation Syndrome (MCAS): When combined with a Histamine Panel.
  • Peri-Menopause Support: When combined with a Metabolic Panel.

Key Areas Analysed

  • Genetic Variations Affecting Hormone Metabolism: Identifies genetic variations that impact how your body metabolises hormones like cortisol, oestrogen, and testosterone, influencing your risk for imbalances.
  • Nutrient-Hormone Interactions: Identifies genetic predispositions to how your body absorbs and utilises nutrients that support hormone function, such as vitamins B6, B12, and folate.
  • Hormone Imbalance Risk Assessment: Identifies your genetic risk for hormonal imbalances and related conditions, enabling personalised care and proactive management.
  • Response to Nutritional Interventions: Identifies how your genetic makeup influences your response to dietary or supplementation strategies aimed at improving hormone levels.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Steroid Hormones
    AKR1C4, CYP17A1, GABRA2, HSD11B1, SRD5A2, SULT2A1 – Identifies genetic variations involved in the synthesis, regulation, and metabolism of steroid hormones like progesterone, testosterone, and cortisol.
  • Oestrogen
    COMT, CYP1A1, CYP1B1, CYP3A4, CYP19A1, ESR1, ESR2, MTHFR, NQO1 – Identifies genetic variations that influence oestrogen metabolism and signalling, related to conditions like oestrogen dominance and deficiency.
  • Detoxification
    ABCB1, GSTM1, GSTP1, SULT1A1, SULT1E1, UGT1A1 – Identifies genes involved in the detoxification of hormones and other substances, supporting the body’s ability to eliminate excess or harmful hormones.
  • HPA Axis
    ADRB1, ADRB2, FKBP5, MTNR1B, OPRM1, TCF7L2 – Identifies genes related to cortisol production and regulation, impacting your stress response, mood, and energy levels.
  • HPG Axis
    ESR1, ESR2, FAAH – Identifies genes that regulate the interaction between the hypothalamus, pituitary, and gonadal glands, which control reproductive hormone levels and function.
By understanding these genetic factors, the Hormones Panel empowers you to make informed decisions about your health. This personalised blueprint helps optimise hormone balance, reduce inflammation, improve reproductive health, and guide lifestyle and dietary choices to support overall well-being.

Gain personalised insights into your genetic thyroid profile, offering valuable information to optimise thyroid function, manage thyroid-related conditions, and improve overall well-being. The Thyroid Panel focuses on thyroid hormone production, metabolism, and regulation, offering a comprehensive view of how genetic factors influence thyroid function and related health issues.

Is it for me?

The Thyroid Panel provides vital insights into a wide range of symptoms, particularly when combined with other reports. It can be especially useful for:
  • Medically unexplained symptoms
    Identifies genetic variations that influence thyroid function, which in turn influences the metabolism of almost every cell in the body, with wide-ranging metabolic, developmental and cardiovascular effects
  • Symptoms of an Underactive Thyroid (Hypothyroidism)
    Identifies genetic factors related to thyroid hormone production and metabolism, helping manage symptoms like weight gain, fatigue, cold intolerance, and depression.
  • Symptoms of an Overactive Thyroid (Hyperthyroidism)
    Pinpoints genetic variations affecting thyroid hormone metabolism, supporting the management of symptoms like anxiety, heat intolerance, heart palpitations, and weight loss.
  • Autoimmune Thyroid Diseases (Hashimoto’s & Graves’ Disease) Reveals genetic predispositions to autoimmune thyroid conditions and provides insights to help manage symptoms including inflammation and thyroid autoantibody production.
  • Thyroid Cancers
    Assesses genetic risks associated with rare thyroid-sensitive cancers, helping identify potential predispositions to thyroid malignancies.
  • Thyroid Disease Risk
    Helps assess your risk of developing thyroid disorders such as goitre, thyroid nodules, and dysfunctions related to thyroid metabolism.

Key Areas Analysed

  • Thyroid Hormone Synthesis: Identifies genetic variations in thyroid hormone production, influencing the levels of thyroxine (T4) and triiodothyronine (T3).
  • Thyroid Hormone Conversion: Reveals genetic factors that affect the conversion of T4 to T3, which impacts thyroid hormone levels and metabolism.
  • Thyroid Hormone Transport: Assesses genetic variations affecting thyroid hormone transporters, influencing the distribution and clearance of thyroid hormones throughout the body.
  • Autoimmune Thyroid Disorders: Identifies genetic risks for autoimmune thyroid diseases like Hashimoto’s and Graves’ disease, including immune function and inflammation.
  • Thyroid Receptor Sensitivity: Reveals genetic variations in thyroid hormone receptors, influencing how cells respond to thyroid hormones and metabolic processes.
  • Thyroid Disease Risk Assessment: Identifies genetic factors that contribute to thyroid disorders such as hypothyroidism, hyperthyroidism, goitre, thyroid nodules, and thyroid cancer.
  • Response to Thyroid Medications: Assesses genetic factors that may influence your response to thyroid medications like levothyroxine (T4) and liothyronine (T3), helping optimise treatment effectiveness.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Thyroid Hormone Synthesis
    CAPZB, FKBP5, GPX1, PDE8B, TG, TSHR – Identifies genetic variations involved in thyroid hormone synthesis and regulation, influencing thyroid hormone levels like T3 and T4.
  • Autoimmune Thyroid Disorders
    CTLA4, FOXE1, HLA-DQA1, HLA-DQB1, PTPN22 – Identifies genetic predispositions to autoimmune thyroid diseases like Hashimoto’s and Graves’ disease, impacting immune function and thyroid health.
  • Inflammation
    CD40, FCRL3, IL6, TNF, GC, VDR – Identifies genes related to inflammation that can affect thyroid function, particularly in autoimmune thyroid conditions.
  • Thyroid Hormone Transport
    SLCO1B1, SLCO1C1 – Identifies genetic variations in thyroid hormone transporters, affecting hormone uptake and distribution throughout the body.
  • Thyroid Hormone Activation
    DIO1, DIO2, BCO1, GC, VDR – Identifies genes involved in the activation and conversion of thyroid hormones, influencing how effectively they function in the body.
  • Thyroid Metabolism
    SULT1A1, SULT1E1, UGT1A1 – Identifies genes that play a role in the metabolism of thyroid hormones, influencing their clearance and availability in the body.
By assessing these genetic factors, the Thyroid Panel empowers you to make informed decisions about your thyroid health. This personalised blueprint helps optimise thyroid function, manage thyroid-related conditions, improve metabolic health, and guide lifestyle and dietary choices to support overall well-being.

Gain vital insights into genetic variations that impact your neurotransmitter balance and nervous system— responsible for the transmission of messages around your mind and body. Gain an understanding of factors influencing mood, sleep, neurodevelopmental disorders, mental health, motor control and more.

Is it for me?

The Nervous System Panel provides vital insights into a wide range of symptoms, particularly when combined with other reports. It can be especially useful for:
  • Neurological Disorders
    Analyses genetic variations that can contribute to a range of neurological symptoms. It can provide vital insights for targeted support for conditions like Alzheimer’s, Parkinson’s, Epilepsy & Multiple Sclerosis.
  • Mood Imbalances & Depression
    Analyses gene variations that impact mood stabilisation, anger, aggression, contentment and relaxation.
  • Sleep
    Analyses gene variations that impact relaxation and sleep as well as those that contribute to states of hyperarousal.
  • Anxiety & Restlessness
    Analyses gene variations that impact nervous system activation, relaxation and ‘fight or flight’ states.
  • Addiction
    Analyses gene variations that can affect neurotransmitters involved in addiction, influencing reward-seeking behaviours, impulse control, stress response, and synaptic plasticity.
  • Obsessive Compulsive Disorders & Mania
    Analyses genetic variations that impact neurotransmitters involved in OCD and Mania including serotonin, dopamine, glutamate, and GABA.
  • Attention Deficit or ADHD
    Analyses genetic variations that impact neurotransmitters like dopamine and norepinephrine, which have a role in producing symptoms like attention deficit, hyperactivity and impulsivity.
  • Impaired movement and Coordination
    Analyses genetic variations that impact neurotransmitters involved in the transmission of messages between the body and the mind like GABA, dopamine and glutamate.

Key Areas Analysed

  • Neurotransmitter Metabolism
    Identifies genetic variations in enzymes and pathways involved in neurotransmitter synthesis, metabolism, and signalling.
  • Brain Health
    Provides insights into genetic factors that influence brain health, including variations related to memory, learning and attention.
  • Cognitive Function
    Provides insights into genetic variations impacting neurological function, executive functioning and other aspects of cognitive procession.
  • Stress Response & Resilience
    Provides insights into the hypothalamic-pituitary-adrenal (HPA) axis, cortisol metabolism, and pathways which can affect resilience, stress-response and susceptibility to stress-related disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD).
  • Inflammation
    Analyses genetic variations involved in inflammation that can contribute to neurodegenerative disease.
  • Neuroprotection & Aging
    Assesses genetic factors that impact neuroprotection, neuroplasticity, and age-related nervous system changes, including antioxidant defense, mitochondrial function, DNA repair, and resilience against neurodegeneration.
  • Neurological Risk Assessment
    Identifies genetic markers that can contribute to the development of neurological disease and neurodevelopmental disorders like Autism Spectrum Disorder, ADHD, Parkinson’s, Epilepsy, Multiple Sclerosis and Alzheimer’s.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Serotonin
    ALDH2, HTR1A, HTR2A, MAOA, MTHFR, SLC18A1 (VMAT), VDR and TPH1 &2
  • Kynurenic Acid
    FKBP5, IFNG and TNF
  • Melatonin
    ASMT and MTNR1B
  • Adrenergic
    ADRB2, COMT, DBH, MAOA, PNMT, SLC6A2 (NET) and SLC18A1 (VMAT)
  • GABA
    ALPL, GAD1, GAD2 and GABRA2
  • Cannabinoid
    CNR1, TRPV1 and FAAH
By analysing these genetic factors, the Nervous System Panel empowers you to make informed decisions about your cognitive and Neurological Health. This personalised blueprint helps optimise neurological function, improve cognitive processing, manage mood, wellbeing and sleep, build neuroplasticity, and guide lifestyle and dietary choices to reduce your long-term risk of neurodegenerative disease.

Gain a broad spectrum of insights about your Cardiovascular & Neurological Health by analysing genetic variations related to the The Apolipoprotein E (APOE) gene which has been associated with susceptibility to cardiovascular disease, insulin resistance and Alzheimer’s. Gain further insights into variations related to methylation, inflammation, toxicity and neuroprotection.

Is it for me?

The APOE Panel offers personalised insights into genetic variations related to lipid metabolism and other factors impacting a range of conditions. It can be especially useful for:
  • High Cholesterol
    Evaluates APOE and MTHFR genetic variants, which may increase the risk of high cholesterol, atherosclerosis and cardiovascular disease.
  • Concerns about Cardiovascular Disease
    Evaluates APOE genetic variants, which may increase the risk of coronary artery disease, heart attack, and other cardiovascular conditions.
  • Concerns about Alzheimer’s
    Evaluates APOE genetic variants, particularly APOE ε4, which may increase the risk of Alzheimer's disease and cognitive decline.
  • Auto-Immune Disease
    Evaluates IFNG and TNF genetic variants, which may increase inflammation and susceptibility to autoimmune conditions like rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
  • Neurological Disorders
    Evaluates BDNF genetic variants, which may influence the risk of neurodevelopmental disorders, cognitive decline, and neurodegenerative diseases like Alzheimer's and Parkinson's.
  • Respiratory Symptoms
    Evaluates GST genetic variants, which may affect detoxification
  • Adverse Reactions to Medication
    Evaluates GST genetic variants, which may influence drug metabolism and increase the risk of adverse reactions or reduced efficacy of certain medications.
  • Insulin Resistance
    Evaluates genetic variants that may influence insulin sensitivity and increase the risk of developing insulin resistance, type 2 diabetes, and metabolic syndrome.

Key Areas Analysed

  • Lipid Metabolism
    Analyses genes which affect the processing and transport of cholesterol and other lipids in the body. Lipid metabolism involves the breakdown, synthesis, and regulation of fats, which are crucial for energy production, cell function, and maintaining healthy cell membranes.
  • Methylation
    Analyses genes involved in methylation, which help control how genes are turned on and off in the body. Methylation is a key process that affects DNA repair, cell function, and overall health by adding small molecules to DNA, helping it work properly.
  • Inflammation
    Analyses genes involved in inflammation and immune response.
  • Detoxification
    Analyses genes which help the body remove toxins and harmful substances. Detoxification is the process of breaking down and eliminating chemicals, pollutants, and waste products to protect the body from damage.
  • Neuroprotection
    Analyses genes which support the health and survival of brain cells, protect the brain from damage, support learning and memory, and promote overall cognitive function.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Lipid Metabolism: APOE
  • Methylation: MTHFR
  • Inflammation: IFNG and TNF
  • Detoxification: GSTM1, GSTT1 and GSTP1
  • Neuroprotection: BDNF
By assessing these genetic factors, the APOE panel empowers you to make informed decisions about your health. This personalised blueprint helps you make diet and lifestyle choices that enhance your body’s natural processes, improve resilience, reduce your risk of disease and support long-term health and well-being.

Gain essential insights into genetic variations that impact how your body metabolises and clears histamine, as well as variations affecting gut health and the processing of substances that interfere with histamine breakdown and elimination.

Is it for me?

The Histamine Panel offers personalised insights into genetic variations related to histamine, gut health and food intolerances, impacting a range of conditions. It can be especially useful for:
  • Suspected or Confirmed Histamine Intolerance
    Analyses genes that can be responsible for inefficient breakdown and removal of histamine resulting in histamine toxicity.
  • Eczema, Hives & Skin Issues
    Analyses genes that can contribute to chronic ‘allergic’ skin reactions like itching, flushing, dermatitis and more.
  • Respiratory Symptoms & Sinusitis
    Analyses genes that can contribute to chronic ‘allergic’ respiratory symptoms like congestion, sneezing, wheezing and sinus headaches.
  • Digestive Issues
    Analyses genes that can contribute to chronic ‘allergic’ gastro-intestinal symptoms like bloating, diarrhoea, nausea and acid reflux.
  • Palpitations, Flushing & Fainting
    Analyses genes that can contribute to chronic ‘allergic’ cardiovascular symptoms like irregular heartbeats, low blood pressure, flushing and fainting.
  • Dizziness, Lethargy & Brain Fog
    Analyses genes that can contribute to chronic ‘allergic’ neurological symptoms like headaches, light-headedness, lethargy and difficulty concentrating.
  • Anxiety or Panic Attacks
    Analyses genes that can contribute to panic attacks, anxiety and restlessness caused by histamine toxicity.

Key Areas Analysed

  • Genetic Variations in Histamine Metabolism
    Identifies genetic variations in enzymes involved in histamine metabolism, such as diamine oxidase (DAO) and histamine N-methyltransferase (HNMT). DAO is responsible for breaking down histamine in the gut, while HNMT metabolizes histamine in other tissues.
  • Susceptibility to Histamine Intolerance
    Identifies genetic variations associated with reduced DAO activity or impaired histamine metabolism which may increase susceptibility to histamine intolerance.
  • Response to Dietary Histamine
    Identifies genetic variations that reduce your capacity to metabolise histamine-rich foods and beverages providing insights that support you to reduce your exposure.

Genes Tested

The Panel analyses the following SNPs, which can shape your biological processes and influence various aspects of your health:
  • Nervous System & Immune System
    HNMT, MAOB, and NAT2
  • Methylation
    MTHFRI
  • Response to Dietary Histamine
    ALDH2, DAO, and GPX1
By assessing these genetic factors the Histamine Intolerance Panel empowers you to make informed decisions about your health. This personalised blueprint can guide dietary and lifestyle interventions to reduce your histamine exposure and optimise your histamine metabolism and lessen the impact of chronic histamine toxicity.

About Our Nutrigenomics Service

When it comes to understanding your health, it’s valuable to have an expert by your side. That’s where Jo comes in. Whether you're managing autoimmune conditions, fertility issues, cancer concerns, or insulin resistance, Jo offers personalised consultations to customise your genomic testing plan, ensuring the right panels are used to address your specific needs.

  • Virtual Consultation: Accessible and convenient at-home consultation via Zoom.
  • Convenient at-home testing: DNA Test Kits delivered straight to your door and completed with a simple cheek swab.
  • Complex Results Made Clear: Expert interpretation— recorded for you to refer back to— so that you can leave with the clarity and confidence to take action.
Our Nutrigenomics service

Nutrigenomics Step by Step

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You’ll provide some health history before consulting with Jo for an Initial Consultation. She’ll get to know your health concerns and develop a beneficial genomic testing plan.

If you’ve already had an Integrative Health Assessment you’ll skip this step —Your Doctor will create your plan in collaboration with Jo.

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We’ll send a DNA test kit to your home address with full instructions about how to take your cheek swab. You’ll return the sample to the Lab where your Genomics will be analysed.

Feel reassured knowing our third party testing suppliers are GDPR compliant and handle your sensitive personal data with the utmost care.
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Once your results are in, we’ll invite you to a session with Jo for full interpretation of your results. She’ll make sure your results are explained clearly, in terms your understand and that you feel confident about the findings. You’ll get a video recording of your session to refer back to throughout your life.
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You’ll receive a comprehensive Genomic Analysis Report that includes genotype results, gene function, SNP impact descriptions, clinically relevant SNPs, nutrient needs and epigenetic effects. You can opt-in to ongoing support or we’ll handover seamlessly to your Integrative Medicine Doctor.

What’s Included?

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1.Tailored Genomic Testing Plan
Receive a targeted Genomic Testing plan based on your medical history and health concerns, designed to optimise your insights.
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2. Advanced Genomic Testing Results
Receive a written report with your genotype results, gene function, SNP impact descriptions, clinically relevant SNPs, nutrient needs and epigenetic effects.
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3. Recommendations & Actions
Understand how to optimise your health outcomes based on your genetic results. Receive precision diet & lifestyle recommendations and a video recording of your interpretation session to refer back to.

Explore Pricing

£375

Initial Consultation

60 Minutes
Full Consultation with Jo Gamble to get to know you, your intention for genetic testing and your medical history. This allows Jo to develop a beneficial testing plan and to interpret your results more fully when the time comes.

Genomic Testing

DNA Testing & 1 Report

15 Minutes
A brief phone call with Jo Gamble to understand more about Nutrigenomics and whether it’s right for you. We can’t give testing recommendations without full consultation but you’ll have a chance to ask any questions you might have.
£236

Each Additional Report

60 Minutes
Full Consultation with Jo Gamble to get to know you, your intention for genetic testing and your medical history. This allows Jo to develop a beneficial testing plan and to interpret your results more fully when the time comes.
£141
14% Discount

Package: DNA Testing & 5 Reports.

60 Minutes
Full Consultation with Jo Gamble to get to know you, your intention for genetic testing and your medical history. This allows Jo to develop a beneficial testing plan and to interpret your results more fully when the time comes.
£688

Results Interpretation

£240

Results Consultation (1-2 Panels )

Virtual Consultation, Written Report, Video Recording
Consult with Jo for full interpretation of your results by Zoom. You’ll receive your report, recommendations and Video recording after the session so that you can make informed health choices now and in the future.
£320

Results Consultation (3-4 Panels)

Virtual Consultation, Written Report, Video Recording
Consult with Jo for full interpretation of your results by Zoom. You’ll receive your report, recommendations and Video recording after the session so that you can make informed health choices now and in the future.
£400

Results Consultation (5 Panels)

Virtual Consultation, Written Report, Video Recording
Consult with Jo for full interpretation of your results by Zoom. You’ll receive your report, recommendations and Video recording after the session so that you can make informed health choices now and in the future.
JO Gamble Advanced Functional Medicine Practitioner & expert in Nutrigenomics

Jo Gamble

IFM Certified Practitioner, Integrative Cancer Fellow, Head of Functional Testing

Special Interests:

Epigenetics & Nutrition, Cancer Support, Fertility, Conception later in life.

Meet Jo Gamble

BA (HONS) DIP CNM AFMCP FELLOW ICT

Jo Gamble is a highly regarded Functional Medicine Practitioner, Integrative Oncology Fellow, and University Lecturer. In 2013, she became the first Nutrigenomics Practitioner in the UK to graduate from the renowned Institute of Functional Medicine. As the Head of Functional Testing at the Forbes Clinic, Jo brings her extensive expertise and scientific rigor to ensure we offer the most advanced, evidence-based Functional Testing available. Over the years, Jo has helped hundreds of patients uncover the root causes of their health concerns, from hormonal imbalances & auto-immune disease to fertility and neurological conditions. She also specialises in supporting individuals in optimising their health and wellbeing throughout their cancer journey.

What Jo’s clients are saying.

FAQ's

You’ll receive a simple cheek swab kit to use at home. Clear instructions guide you through collecting your sample quickly and easily, and when you’re done, you just return it in the prepaid envelope provided.

Yes—your privacy is our priority. Once received, samples are anonymised using a barcode. The LifecodeGX lab is UK-based, ISO-certified, and fully GDPR-compliant. DNA samples are destroyed after 3 months. Genotyping data is marked for destruction at 5 months and permanently destroyed by 6 months. Your DNA and report data are never shared with or sold to third parties.

No. A consultation is always required to ensure your results are reviewed in the right context. This way, your practitioner can explain what the findings mean for your health and guide you in applying them effectively.

Once the lab receives your DNA sample, analysis usually takes 3–4 weeks. You’ll then receive your personalised reports and go through them with your practitioner to explore what they mean for your health and well-being.

Your doctor will use your DNA insights to better understand your unique genetic profile—how it may influence nutrition, lifestyle, and long-term health. This information helps shape a care plan that is truly personalised to you. Jo will collaborate closely with your Doctor to ensure the insights are integrated into your plan. 

Genomic testing needs to be interpreted by a trained professional with experience in applying the insights to support your health. As Head of Functional Testing, Jo has an unparalleled understanding of all of our Functional Testing including Nutrigenomics. She lectures internationally training healthcare professionals to work with this kind of data. Your tests will be interpreted by Jo so you can benefit from her expertise. 

You can certainly request more than 5 panels, however you’ll need to be aware that you’ll need a very extensive consultation to be able to interpret this many reports in full. It may also be challenging to work with this many recommendations and implement them into your daily life. If you’d like to order more than 5 reports, our Clinic support team will guide you with booking an appropriate consultation. 

Still have Questions?

From The Root Up:

A whole approach to health

Your genetic blueprint offers invaluable insight into your body’s unique needs, but our Integrative Health Assessments consider the entire picture—environmental, psycho-emotional, biological, and more. We’ll provide personalised recommendations that blend advanced Nutrigenomics insights with customised therapies to support your overall health. Book an Integrative Health Assessment today to receive a comprehensive, holistic plan that’s just for you.

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references to be added

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